Study and trial results » To Download PDF's Click Here...
Study 01 » To Download PDF's Click Here...
Prevention and treatment of Seasonal Allergic Rhinitis.
Description
Josling P, Steadman S. Use of cellulose powder for the treatment of seasonal allergic rhinitis Adv Ther. 2003 Jul-Aug;20(4):213-9. Open Clinical Trial.
Population
102 participants (66 female and 36 male).
Measurements and Results
Utilized a questionnaire format with 5 point rating scale (score of 5 represents no symptoms and complete control.) Overall average daily score was reported as 3.8 (men) and 3.9 (women) representing a minimum 77% success rate, in the ability of Nasaleze to control hay fever. Over 35% of volunteers recorded an average daily score in excess of 4.0 and over 80% of volunteers recorded a score above 3.0 indicating a definite treatment success. Only 12% of volunteers recorded a daily average score under 2.9, a total control of symptom score of approximately 88%. Cellulose powder earned on average a higher score than all pharmaceutical alternatives. Relief was obtained within 0.1-3 hours. Rarely, an uncomfortable sensation in the back of the throat was the only side effect reported (10%).
Study 02 » To Download PDF's Click Here...
Effect of Nasaleze on symptoms of hayfever in adults and the difference in amount of and type of rescue medication required for adult hayfever sufferers to control their symptoms during grass pollen season.
Description
Emberlin JC, Lewis RA. A double blind placebo controlled trial of inert cellulose powder for the relief of symptoms of Hay fever in adults. Curr Med Res Opin 2006;22(2)275-85.
Population
97 hay fever sufferers (aged 18 years and older).
Measurements and Results
The amount of rescue medication used by the placebo group (over all and in individual categories e.g. antihistamines, nasal sprays and eye drops) was significantly greater than that used by the active (Nasaleze) group. Few differences in the symptom scores during the trial for the two groups were reported. Nasaleze significantly reduced the need for rescue medication. No adverse effects were reported.
Study 03 » To Download PDF's Click Here...
Measure of improvement in nasal muco-ciliary clearance and PNIFR (peak inspiratory flow rate) in children with allergic rhinitis.
Description
Aivazis V, Bourli E, Maratou E et al. Study of Mucociliary Clearance and Peak Nasal Inspiratory Flow Rate in Children Before and After Therapy with Natural Cellulose Powder. U of Thessaloniki, Greece. Presented at World Allergy Congress in Munich, W Germany June 2005, also published in Nea Pediatrica Chronica, June 2005, Vol 5 no 2. Open Clinical Trial.
Population
100 children with allergic rhinitis (age 1.5Ð18, mean 8.2 years).
Measurements and Results
Significant improvement in Nasal Mucous Clearance (reduced from 39 minutes to 18.15 minutes) and PNIFR value (increased up to 25.7%) was reported. The improvement in the Nasal Mucous Clearance and PNIFR values were due to the regeneration and normalization of the ciliaryÕs epithelium. Cellulose allows the filtration of the inhaled air and protects the nasal mucosa from irritants such as allergens, pollutants, and viruses. Mucociliary Clearance and PNIFR improve since allergic inflammation and edema are avoided.
Study 04 » To Download PDF's Click Here...
Efficacy of Nasaleze for use in hayfever via pollen provocation tests.
Description
Emberlin JC, Lewis RA. A double blind, placebo controlled trial of inert cellulose powder for the relief of symptoms of hay fever in adults. Presented as a Poster at EAACI, Vienna June 2006.
Population
22 volunteers.
Measurements and Results
Preliminary findings show significant differences in several classes of symptoms with the Nasaleze yielding a significant reduction in symptoms compared with placebo powder.
Study 05 » To Download PDF's Click Here...
Dust mite challenge study.
Description
Emberlin JC, Lewis RA. Double blind placebo controlled cross-over trial of Nasaleze by nasal provocation tests. Presented as a Poster EAACI, Gothenburg June 2007. Curr Med Res Opin; Vol 23; No 10; 2007, 2423-2431.
Population
15 volunteer adults (aged 18 years and older).
Measurements and Results
Symptom scores, ECP Eosinophil cationic protein) and nasal peak inspiratory flow (PIFn), and nasal peak expiratory flow (PEFn) will be analyzed for each participant in relation to the type of powder applied as individual controls. The measures will also be analyzed for comparisons between participants for variance and overall effects.
Study 06 » To Download PDF's Click Here...
Clinical study of Nasaleze for relief of allergy symptoms including sneezing, runny nose, itchy and watery eyes.
Description
Vlahtis K. Clinical Study Results Summary. Presented at the Pan-Hellenic Conference of ENT Specialists on 19th March 2004 in Thessaloniki, Greece. Open Clinical Trial.
Population
40 participants.
Measurements and Results
All participants were using a pharmaceutical treatment (decongestant 35%, corticosteroids 42.5%, antihistamines 2.5%, corticosteroid/antihistamine combination 20%) at the beginning of the study. Participants were asked to discontinue use of this medication during the study. After 3 weeks of use, 85% of participants realized improvement in their allergy symptoms. After 6 weeks of use, 90% of participants realized improvement in their symptoms.
Study 07 » To Download PDF's Click Here...
Nasaleze cellulose powder delays house dust mite allergen (Der p1) diffusion in vitro.
Description
Nasaleze powder is applied to the nose where it absorbs water and forms a gel which is thought to act as a mechanical barrier against allergens. Purpose of the study was to investigate this theory about the mechanism of action of the gel in relation to house dust mite allergen (Der p1). Poster presented at the XXVII Congress of the European Academy of Allergology and Clinical Immunology Barcelona, Spain 7Ð11 June 2008. Bernadette Diethart and Professor Jean Emberlin of University of Worcester, UK; Richard Lewis, Worcestershire Royal Hospital, United Kingdom
In vitro study
Measurements and Results
The diffusion of Der p1 was delayed by both gel layers, the amount of allergen diffused through the agar gel was not significantly different from the baseline values. Nasaleze cellulose powder does delay the diffusion of Der p1 significantly but due to the small size of allergenic proteins it is not able to act as an impermeable barrier. Therefore regular re-application of the powder to the nostrils has to be suggested for optimum efficacy of the product in the prevention and alleviation of allergic rhinitis.
Study 08 » To Download PDF's Click Here...
Preventing Airborne Infection With an Intranasal Cellulose Powder Formulation (Nasaleze Travel).
Description
A dual-centered, randomized, blinded study so investigators could determine whether the level of airborne infection could be significantly reduced in patients randomly assigned to treatment with either Nasaleze cellulose extract alone or a combination of Nasaleze cellulose and powdered garlic extract (PGE). Professor R Hiltunen, PhD, PharmD University of Helsinki, Finland; PD Josling, BSc (Hons) Herbal Research Centre Battle, United Kingdom; MH James Nasaleze Limited, Isle of Man. Advances In Therapy Volume 24 No. 5 September/October 2007
Population
52 participants.
Measurements and Results
The results clearly favored the Nasaleze Travel combination formulation. They indicate that a significant reduction in the number of airborne infectious pathogens picked up by volunteers was seen in this group as opposed to outcomes in the Nasaleze cellulose powder alone group.
Review » To Download PDF's Click Here...
A Review of the Efficacy and Safety of Nasaleze¨ in the Prevention and Management of Allergic Rhinitis.
Description
A review paper by Professor Patrick JD Bouic, Division of Medical Microbiology, Dept of Pathology, University of Stellenbosch, South Africa. Nasaleze has been on sale since 1994 in the UK, however this review paper was necessitated by the fact that the product was unknown at the time of its launch in South Africa. Published in The Open Allergy Journal, 2008, 1, 1-4.
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